Atharva Tilewale
Bioinformatician & Computational Biologist
I am a computational and experimental biotechnologist interested in protein engineering, enzyme design, molecular simulations, and AI-driven biotechnology.
My current research focuses on improving enzyme thermostability using structure-guided methods, molecular dynamics, and free-energy-based analysis. Alongside research, I enjoy developing open-source computational tools and workflows that make structural biology and bioinformatics more accessible and efficient.
My long-term goal is to contribute to computational protein engineering and translational molecular design through research that combines scientific depth with practical impact.
Research Interests
Areas where biology meets computation
Education & Experience
My academic and research journey
Visiting Research Student
University of Edinburgh, UK
Master's dissertation with Michel Group. Focus: enzyme thermostability enhancement using molecular dynamics and alchemical free energy calculations.
Summer Research Fellow
Bhabha Atomic Research Centre (BARC), Mumbai
IASc-INSA-NASI Fellowship. Research on DNA-binding proteins in Deinococcus radiodurans and radiation resistance mechanisms.
Master's in Biotechnology
Gujarat Biotechnology University
- Dissertation research in CxBL Lab on rational protein engineering using AI embeddings and free energy calculations for enzyme design
- Developing AI assisted protein engineering pipeline for zero shot stable mutant prediction
Bachelor's in Biotechnology
Savitribai Phule Pune University
Computational screening of phytochemicals for drug candidates targeting 5-alpha reductase.
Technical Skills
Tools and technologies I work with
Programming
- Python
- R
- Bash/Shell
- JavaScript
- HTML
- CSS
Bioinformatics
- BioPython
- Schrodinger
- GROMACS
- RoseTTA
- BoltzGen
- RFDiffusion
- OpenMM
- BindCraft
- PyMOL
- AlphaFold/Boltz
Data Science
- Pandas/NumPy
- Scikit-learn
- Matplotlib/Seaborn
- Jupyter Notebooks
- Statistical Analysis
DevOps & Tools
- Git/GitHub
- Docker
- Linux/Unix
- HPC
- Flask
- Nextflow
- Snakemake
- VS Code
Awards & Recognition
Hackathon victories and professional recognition
Edinburgh Biohackathon 2026
Organized by: PRIMED Edinburgh
University: University of Edinburgh, UK
Won first prize in the Fibre Synthesis Challenge hosted by Quas Drinks Ltd, titled "The Sugar Spinner: Engineering a Plug-and-Play Biological System for In-Situ Fibre Synthesis."
ML for Protein Design Hackathon
Organized by: Locksmith Bio x IBAB Bangalore
Theme: De Novo Antibody Design
Won first prize in engineering next-generation immune checkpoint therapeutics against PD-1/PD-L1.
IASc-INSA-NASI Summer Research Fellowship Program (SRFP) 2025
Institute: Bhabha Atomic Research Center (BARC), Mumbai
Selected fellow for conducting research on Deinococcus radiodurans DNA-binding proteins and radiation resistance at BARC.
Summer Research Internship Program (SRIP) 2025
Institution: IIT Gandhinagar
Selected fellow for the prestigious Summer Research Internship Program 2025.
Research Philosophy
What drives my work
"I believe that the future of biology lies in the seamless integration of wet-lab experiments and computational analysis. By building accessible, open-source tools, we can democratize scientific research and accelerate discoveries that benefit humanity."— Atharva Tilewale
Interested in Collaborating?
I'm always open to discussing new research ideas, tool development, or collaborative projects.
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